The Mechanism of the Davy Test for Strychnine

F. Sánchez-Viesca, Reina Gómez
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引用次数: 4

Abstract

The chemistry of a spot test for identification of a bioactive compound is important the more if the substance is strychnine. This converts the test in a toxicological assay with forensic application. The Davy test is based on the oxidation of strychnine by means of potassium ferricyanide in the presence of sulphuric acid. This Theoretical Organic Chemistry study reveals the reaction series that occurs during the test, the electron flow is provided step by step. The process is an electron-transfer oxidation, from the alkaloid to the multi-functional final product having two lactams, a ketone and a carboxylic acid. The involved reactions are electrophilic attack to double bond, hydrogen elimination, free radical subtraction, isomerization, alcohol oxidation, epoxide formation, hydrolysis, concerted reaction mechanism to ketone and aldehyde via carbon-carbon fission, and oxidation of aldehyde to carboxylic acid. All is in accordance with the chemical deportment of the involved compounds and is supported by the references.
士的宁戴维试验的机理
如果该物质是士的宁,则对生物活性化合物进行鉴定的现场试验的化学性质尤为重要。这将测试转化为具有法医应用的毒理学分析。戴维试验是在硫酸存在的情况下,用铁氰化钾氧化士的宁。本理论有机化学研究揭示了试验过程中发生的一系列反应,并逐步提供了电子流。该过程是电子转移氧化,从生物碱到具有两个内酰胺,酮和羧酸的多功能最终产物。所涉及的反应有:亲电攻击双键、氢消除、自由基减去、异构化、醇氧化、环氧化物生成、水解、碳-碳裂变生成酮和醛的协同反应机制、醛氧化生成羧酸等。所有这些都符合所涉及化合物的化学性质,并得到参考文献的支持。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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