Сorrelations of EEG with Clinical Scores in Depressive Patients with a History of Suicide Attempts

A. Iznak, E. Iznak, E. Damyanovich, I. Oleichik
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Abstract

Study Objective: to clarify the role of neurophysiological mechanisms in the pathogenesis of suicidal behavior in young depressed patients with a history of suicidal attempts. Study Design: open study. Materials and methods. The study included 35 female patients aged 16-25 years. Relationships between pre-treatment quantitative clinical scores (according to the HDRS-17 scale) and values of the absolute spectral power of the background resting EEG in narrow frequency sub- bands were analyzed. Study Results. Significant negative correlations (p < 0.05) between the EEG parameters and the sum of depression cluster scores of the HDRS-17 scale indicate reduced activation of the frontal-anterotemporal cortex areas of both hemispheres (according to the values of the alpha2 EEG sub-band (9–11 Hz) spectral power in F7, F3, F4 and F8 leads), and especially, of the left anterior temporal region (according to the values of the EEG beta2 sub-band (20–30 Hz) spectral power in F7 lead). In addition, these patients are characterized by a somewhat reduced functional state of the central temporal-parietal zones of the right hemisphere in the form of significant positive correlations (p < 0.05–0.01) of the slow-wave delta (2–4 Hz), theta1 (4–6 Hz) and theta2 (6–8 Hz) EEG activity spectral power values in F4, C4, T4 and P4 leads with the sum of anxiety cluster scores of the HDRS-17 scale. Conclusion. The results obtained make it possible to clarify the neurophysiological mechanisms of the pathogenesis of suicidal behavior in young depressive patients. Keywords: depression, young age, suicide attempts, quantitative EEG.
有自杀企图史的抑郁症患者脑电图与临床评分的关系Сorrelations
研究目的:探讨神经生理机制在有自杀企图史的青少年抑郁症患者自杀行为发病机制中的作用。研究设计:开放式研究。材料和方法。该研究包括35名年龄在16-25岁之间的女性患者。分析治疗前临床定量评分(根据HDRS-17量表)与背景静息脑电窄频子带绝对谱功率值的关系。研究的结果。脑电参数与hdr -17量表抑郁聚类得分之和呈显著负相关(p < 0.05),表明两脑半球额颞叶前皮层区域的激活减少(根据F7、F3、F4和F8导联的阿尔法2脑电子带(9-11 Hz)频谱功率值),尤其是左颞叶前部区域的激活减少(根据F7导联的阿尔法2脑电子带(20-30 Hz)频谱功率值)。此外,患者右半球中央颞顶区功能状态有所降低,F4、C4、T4、P4导联慢波δ (2-4 Hz)、θ 1 (4-6 Hz)、θ 2 (6-8 Hz)脑电活动谱功率值与HDRS-17焦虑类得分和呈显著正相关(p < 0.05 ~ 0.01)。结论。本研究结果为阐明青少年抑郁症患者自杀行为的神经生理机制提供了可能。关键词:抑郁症,青少年,自杀企图,定量脑电图。
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