Intrahepatic Mass-Forming Extramedullary Hematopoiesis in a Patient With Sickle Cell Disease: Case Report and Literature Review

IF 0.2
Osama Al-Dalahmah, Simona De Michele, D. Sperling, K. O'toole, A. Iuga
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引用次数: 1

Abstract

Extramedullary hematopoiesis (EMH) is characterized by the expansion of hematopoietic tissue outside the bone marrow niche. It occurs when bone marrow function is insufficient and typically presents with generalized hepatosplenomegaly. We describe a rare case of mass-forming EMH that presented as two intrahepatic lesions, radiologically well-demarcated and nonenhancing on computed tomography. On magnetic resonance imaging, the lesions appeared T1 hypointense and T2 hyperintense with restricted diffusion. The lesions were discovered at the surgical workup for acute cholecystitis in a patient with previous history notable for sickle cell disease. Given the radiological concern for a neoplastic process, an ultrasound-guided biopsy was performed and diagnosed histologically as EMH. A review of the current literature detailing the common clinical, radiological, and pathological presentation of EMH is provided.
镰状细胞病患者的肝内团块形成髓外造血:病例报告和文献复习
髓外造血(EMH)的特点是骨髓壁龛外造血组织的扩张。当骨髓功能不足时发生,典型表现为全身性肝脾肿大。我们描述了一个罕见的肿块形成的EMH,表现为两个肝内病变,放射学上界限清楚,计算机断层扫描无增强。mri表现为T1低信号和T2高信号,弥散受限。该病变是在急性胆囊炎的外科检查中发现的,患者既往有镰状细胞病病史。考虑到肿瘤过程的放射学问题,超声引导下进行活检并在组织学上诊断为EMH。回顾当前文献详细介绍EMH的常见临床,放射学和病理表现。
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期刊介绍: Each issue of Pathology Case Reviews examines one vital theme in the field with peer-reviewed, clinically oriented case reports that focus on diagnosis, specimen handling and reports generation. Each theme-oriented issue covers both histopathologic and cytopathologic cases, offering a comprehensive perspective that includes editorials and review articles of the newest developments in the field, differential diagnosis hints, applications of new technologies, reviews of current issues and techniques and an emphasis on new approaches.
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