Acceptability and results of Corifollitropin alfa and Desogestrel for ovarian stimulation in oocyte donors

Abstract

During the last decade, increased attention has been paid to the development of new treatment approaches in assisted reproduction. It is crucial to establish a safe, effective and comfortable stimulation regimen to increase acceptability and reduce patients’ treatment stress and the high dropout rate that occurs after a failed treatment.

The present study aimed to describe the acceptance and results of a novel treatment regimen, consisting of Corifollitropin alfa (CFT) for ovarian stimulation (OS) and oral Desogestrel (DSG) for control of endogenous LH rise in oocyte donors (OD) who had a previous OS cycle with CFT and GnRH-antagonist (ANT) for LH suppression. This retrospective, cohort study, was performed in a private infertility clinic including 42 oocyte donors between April 1st 2016 and April 1st 2017. To evaluate the degree of acceptability of the DSG treatment cycle, a satisfaction questionnaire was used (EFESO questionnaire). When analyzing results, the degree of satisfaction observed with the novel stimulation protocol was high, without finding significant differences between both groups of treatment related to clinical variables.