A SQUID measurement system for immunoassays

Applied Superconductivity Pub Date : 1999-10-01 DOI:10.1016/S0964-1807(99)00014-9

H Matz , D Drung , S Hartwig , H Groß , R Kötitz , W Müller , A Vass , W Weitschies , L Trahms

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引用次数: 69

Abstract

A SQUID measurement system is presented that was developed for analysis of antigen–antibody reactions in fluid samples. The detection method is based on the signal generated by the remanent or relaxing magnetization of nanoparticles which are attached as labels to the antibodies. The measurement system involves two 7.2-mm-diameter multiloop SQUID chip magnetometers (type W7A) with a typical field noise of √ $S_{B}$ =1.5 fT/√ $Hz$ arranged as an electronic gradiometer with a baseline of 160 mm. It is embedded in a liquid helium dewar with a tail bottom allowing 6 mm distance between SQUID and room temperature. A sophisticated direct-coupled read-out-electronics was realized with a bandwidth of 8 MHz. The read-out-electronics can be reset within τ_R ⩽0.5 μs. A 2 channel control unit was developed which enables environmental noise reduction. Data are acquired by a PC-controlled 8 channel system with 16-bit resolution and a maximum sampling frequency of f_s=196 kHz. First measurements are presented.

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用于免疫分析的SQUID测量系统

提出了一种用于分析液体样品中抗原-抗体反应的SQUID测量系统。检测方法是基于纳米粒子作为标签附着在抗体上的剩余或放松磁化产生的信号。测量系统包括两个直径为7.2 mm的多回路SQUID芯片磁强计(W7A型)，典型场噪声为√SB=1.5 fT/√Hz，布置为电子梯度计，基线为160 mm。它被嵌入在一个液氦杜瓦瓶尾部底部允许鱿鱼和室温之间6毫米的距离。一个复杂的直接耦合读出电子器件以8兆赫的带宽实现。读出电子学可在τR≤0.5 μs内复位。开发了一个2通道控制单元，可以降低环境噪声。数据由pc控制的8通道系统采集，16位分辨率，最大采样频率fs=196 kHz。首先给出了测量结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Applied Superconductivity

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