The pattern of hippocampal neuronal, LTP and unilateral labyrinthectomy in male rats: the role of exercise and curcumin

Abstract

A wide range of cognitive disorders, long-term potentiation (LTP) disorders, and biochemical changes have been reported in labyrinthectomy situations in the hippocampus of rodents. In order to investigate whether exercise and/or curcumin induce LTP and increase neurons in the hippocampus of unilateral labyrinthectomy male rats, after undergoing labyrinthectomy, animals were subjected to treadmill exercises after the intraperitoneal injection of curcumin five days per week, for 30 days. An increase of LTP and neuron count of the hippocampus was observed in unilateral labyrinthectomy rats. Interestingly the combination of exercise and curcumin did not enhance LTP in unilateral labyrinthectomy rats. These findings demonstrated that treadmill exercise and curcumin individually, significantly affect reinforcement of many of the pathological processes playing a role in increasing memory in unilateral labyrinthectomy situations.