The Effect of Iron Deficiency Anemia on the Child Death Related to HIV/AIDS Infection: Meta-Analysis

Abstract

Background: A quarter of the world's popula­tion suffers from iron deficiency anemia with various causes. Anemia has an impact on a child's quality of life, even if it is of mild or moderate severity. This study aims to analyze the effect of hemoglobin levels on the mortality of children infected with HIV/AIDS using a meta-analysis. Subjects and Method: This was a systematic review and meta-analysis. Article searches were conducted using electronic databases, namely Google Scholar and PubMed. Article sub­mission time is 1 month. Article search is done by several methods, namely boolean operators, handsearching, and keywords and MesH. The articles included in this study are articles that have a cohort study design. The systematics of article collection was carried out using the PRISMA-P flow chart. All articles were ana­lyzed using the Review Manager 5.3. Results: Hemoglobin < 10 g/dl (aHR= 2.80; 95% CI=2.02 to 3.89; p<0.001), hemoglobin <9 g/dl (aHR= 1.82; 95% CI=1.31 to 2.51; p<0.001), and hemoglobin <8 g/dl (aHR= 1.77; 95% CI=1.43 to 2.20; p<0.001) has an effect on mortality of children infected with HIV/AIDS. Conclusion : Low hemoglobin levels increase the risk of death in children infected with HIV/AIDS. Keywords: hemoglobin, anemia, iron, child death Correspondence:  Dyah Ambarwati. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: ambarwati.dyah27@gmail.com. Mobile: +6287735486570 Journal of Epidemiology and Public Health (2021), 06(02): 158-169  https://doi.org/10.26911/jepublichealth.2021.06.02.03