In vivo-activation of photodynamic hematoporphyrin-derivative (HPD) by HIFU

Abstract

The object of the authors' investigations is the in vivo-activation of photosensitizing agents by high energy ultrasound (HIFU) in order to minimize side effects and to increase penetration depth of photodynamic treatments. Animal experiments were carried out using the Dunning rat prostrate adenocarcinoma R3327-AT1 in Copenhagen rats. Macroscopic treatment response was evaluated and biologically graded. The authors were able to assess a synergistic tissue interaction of HIFU (f=1.18 MHz, I=3530 W/cm/sup 2/) and hematoporphyrin-derivative.