Crystallization Optimizing of Cefradine

Abstract

Cefradine crystallization was studied under different conditions. The optimal conditions for crystallization were: dissolving temperature, 15°C; initial temperature in crystallization, 30°C; cooling temperature in crystallization, 0°C; and adding 1,2-propanediol as adjuvant agent with a volume ratio 0.2 of water solution. The yield of cefradine crystallization is about 92% under these conditions. The purity of cefradine crystals is over 98% under the same conditions. The average size of cefradine crystal is 500 μm. The content of cefalexin in crystal is reduced to only 0.36%.