Comparative, randomized-controlled trial on efficacy and safety of Lactobacillus rhamnosus GG and Saccharomyces boulardii in treatment of acute diarrhea in Indian children (COMPARE-GG trial)

S. Biswas, B. Bal
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Abstract

Background: Probiotics are routinely prescribed to boost gut health and reduce severity of diarrhea. This study aimed to compare the efficacy and safety of Lactobacillus rhamnosus GG (LrGG) and Saccharomyces boulardii as an adjunct treatment for acute diarrhea in Indian children aged 6–36 months. Methods: In this single-center, open label, comparative, randomized controlled study, children were randomized into three groups (n=35, each) and provided either low osmolarity oral rehydration solution (ORS) and zinc (20 mg/day) alone or ORS+Zinc supplemented with one of the two probiotic preparations, LrGG ATCC 53103 or S. boulardii CNCM 1-745. Children were monitored every 8 hours after admission and the duration of diarrhea and hospital stay, and stool frequency were evaluated. Results: Of the total 105 children enrolled in the study, majority were aged between 13–24 months (40%). LrGG significantly reduced the mean duration of diarrhea by nearly 19 hours, when compared to the control group (p=0.003), while reduction by S. boulardii was not significant. The mean hospital stay duration for control group was about 6 days, which was significantly reduced (p=0.0001) by nearly 23 hours by LrGG, and non-significantly by S. boulardii. On day 2, LrGG significantly reduced stool frequency by 32.31%, as compared to 27.44% reduction in control group. S. boulardii reduced stool frequency by 31.76%, which was not statistically significant compared to that in control group. Conclusions: LrGG showed statistically significant reduction in duration of diarrhea and hospital stay, when compared against the group receiving ORS+zinc either alone or with S. boulardii.
鼠李糖乳杆菌GG与博氏酵母菌治疗印度儿童急性腹泻疗效及安全性的对照、随机对照试验(COMPARE-GG试验)
背景:益生菌通常用于促进肠道健康和减轻腹泻的严重程度。本研究旨在比较鼠李糖乳杆菌GG (LrGG)和博氏酵母菌作为辅助治疗6-36月龄印度儿童急性腹泻的疗效和安全性。方法:在这项单中心、开放标签、比较、随机对照研究中,儿童被随机分为三组(n=35,每组),分别提供低渗透压口服补液(ORS)和锌(20 mg/d),或ORS+锌补充两种益生菌制剂中的一种,LrGG ATCC 53103或博氏沙门氏菌CNCM 1-745。入院后每8小时监测患儿腹泻时间和住院时间,并评估大便频率。结果:参与研究的105名儿童中,大多数年龄在13-24个月之间(40%)。与对照组相比,LrGG显著减少了腹泻的平均持续时间近19小时(p=0.003),而博氏沙门氏菌的减少并不显著。对照组的平均住院时间约为6天,LrGG显著减少了近23小时(p=0.0001),而S. bowlardii则无显著差异。在第2天,LrGG显著减少粪便频率32.31%,而对照组减少了27.44%。博氏沙门氏菌使患者排便次数减少31.76%,与对照组相比差异无统计学意义。结论:与单独或与博氏沙门氏菌联合接受ORS+锌治疗的组相比,LrGG在腹泻持续时间和住院时间方面具有统计学意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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