ANALGETICACTIVITY TEST OF ETHANOL EXTRACT OFTAMARIND LEAVES (TamarindusIndica L.) TO MALEMICE OF SWISS STRAIN

Abstract

Tamarind is a medicinal plant that has benefits as an antiseptic, antipyretic and analgetic (anti-pain). Pain is an unpleasant sensory and emotional experience due to actual or potential damage.The purpose thisstudy to determine the optimal analgetic and dosage activity of tamarind leaf ethanol extract on male mice swiss strain induced by acetic acid. The method used is analysis of results by observing the amount of stretching of mice every five minutes for an hour. The cumulative amount of stretching in mice to calculate the analgetic activity was obtained from the amount of stretching of mice induced by acetid acid intraperitoneally within 30 minutes after orally induced. Statistical analgetic data using kolmogorov-smirnov normality test, test of homogenity of variances followed by Anova test and post hoc tests using SPSS 24.0 for windows. Percentanalgesic activity of ethanol extract of leaves tamarind dosage 5%, 10%, 20%wererespectively (9,81 ± 2,24)%, (24,68 ± 2,10)% and (36,39 ± 3,06)%. Ethanol extract of leaves tamarind dosage 20% provide the most optimal activity analgesic