Studies on antitumor activity spectrum of doxycycline

Abstract

In this study, in vitro (21 kinds of cell lines) and in vivo (four kinds of tumor-bearing mouse models) experiments were performedto determine the anticancer effect of doxycycline. This drug may elicit a strong inhibitory effect on cancer cells and improve thesurvival condition of mice. This study also preliminarily investigated the inhibitory effect of doxycycline on different kinds oftumor cells.