Non-adherence to pharmacotherapy and its associated factors in outpatients with rheumatoid arthritis

IF 2.4 Q3 PHARMACOLOGY & PHARMACY

Pharmacy Practice-Granada Pub Date : 2023-06-30 DOI:10.18549/pharmpract.2023.2.2822

A. Jarab, S. R. A. Heshmeh, W. Al-Qerem, T. Mukattash, R. Beiram, S. Aburuz

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引用次数: 0

Abstract

Background: Despite the availability of effective pharmacotherapy for the management of rheumatoid arthritis (RA), health outcomes are suboptimal due to poor adherence to the prescribed treatment. Limited research has been conducted to investigate medication non-adherence and its associated factors among patients with RA. Objective: This study aimed to assess medication adherence and to explore the factors associated with medication non-adherence among outpatients with RA in Jordan. Methods: The current cross-sectional study was conducted at outpatient rheumatology clinics at two teaching hospitals in Jordan. Variables including socio-demographics and biomedical variables, in addition to disease and medication characteristics, were collected using medical records and custom-designed questionnaire. Medication adherence was assessed using the validated 5-item Compliance Questionnaire for Rheumatology. Stepwise Logistic Regression analysis was performed to identify the factors that are independently and significantly associated with medication non-adherence. Results: A total of 261 patients participated in the study, from which, 43.3% were found non-adherent. Binary regression analysis results revealed that low monthly income (OR= 0.239, CI= 0.130-0.440, P<0.01), the presence of chronic respiratory disease (OR= 2.727, CI= 1.059-7.022, P<0.05), lower medication necessity scores (OR= 1.177, CI= 1.10-1.259, P<0.01) and higher concerns about RA medications (OR= 0.917, CI= 0.860-0.978, P<0.01) were significant and independent predictors of medication non-adherence in patients with RA. Conclusion: Future pharmaceutical care and clinical pharmacy service programs should emphasize medications benefits and minimizing medication-related concerns by selecting safe medications and providing guidance on mitigating side effects, particularly for RA patients who have low income and those who suffer from other comorbid diseases.

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门诊类风湿关节炎患者药物治疗不依从及其相关因素

背景:尽管类风湿性关节炎(RA)有有效的药物治疗，但由于对规定治疗的依从性差，健康结果不理想。有限的研究调查了RA患者的药物依从性及其相关因素。目的:本研究旨在评估约旦门诊类风湿性关节炎患者的药物依从性，并探讨与药物依从性相关的因素。方法:目前的横断面研究在约旦两所教学医院的风湿病门诊进行。除了疾病和药物特征外，还使用医疗记录和定制问卷收集了包括社会人口统计学和生物医学变量在内的变量。使用经验证的风湿病依从性问卷(5-item Compliance Questionnaire for Rheumatology)评估药物依从性。采用逐步Logistic回归分析确定与药物不依从性独立且显著相关的因素。结果:共261例患者参与研究，其中43.3%为非依从性。二元回归分析结果显示，月收入低(OR= 0.239, CI= 0.130 ~ 0.440, P<0.01)、存在慢性呼吸系统疾病(OR= 2.727, CI= 1.059 ~ 7.022, P<0.05)、用药必要性评分低(OR= 1.177, CI= 1.10 ~ 1.259, P<0.01)、对RA用药关注度高(OR= 0.917, CI= 0.860 ~ 0.978, P<0.01)是RA患者用药不依从的显著独立预测因子。结论:未来的药学服务和临床药学服务项目应强调药物的益处，并通过选择安全的药物和提供减轻副作用的指导来减少药物相关的担忧，特别是对于低收入和患有其他合并症的RA患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacy Practice-Granada PHARMACOLOGY & PHARMACY-

CiteScore

3.90

自引率

4.00%

发文量

113

审稿时长

20 weeks

期刊介绍： Pharmacy Practice is a free full-text peer-reviewed journal with a scope on pharmacy practice. Pharmacy Practice is published quarterly. Pharmacy Practice does not charge and will never charge any publication fee or article processing charge (APC) to the authors. The current and future absence of any article processing charges (APCs) is signed in the MoU with the Center for Pharmacy Practice Innovation (CPPI) at Virginia Commonwealth University (VCU) School of Pharmacy. Pharmacy Practice is the consequence of the efforts of a number of colleagues from different Universities who belief in collaborative publishing: no one pays, no one receives. Although focusing on the practice of pharmacy, Pharmacy Practice covers a wide range of pharmacy activities, among them and not being comprehensive, clinical pharmacy, pharmaceutical care, social pharmacy, pharmacy education, process and outcome research, health promotion and education, health informatics, pharmacoepidemiology, etc.