Metabolic regulation in innate immunity

Abstract

Abbreviations: CNS, central nervous system; G6P, glucose 6-phosphate; GluT, glucose transferase; ATP, Adenosine three phosphate; NADPH, nicotinamide adenine dinucleotide phosphate; MAPKS, mitogen activated protein kinases; ROS/RNS, reactive oxygen/reactive nitrogen species; G6PD, glucose-6-phosphate dehydrogenase; NF-κB, nuclear factor-κB nox: NADPH Oxidase 2; MIF, migration inhibitory factor; PKC, protein kinase C; TLR, tolllike receptors; PRRS, pattern recognition receptor; Myd88, myeloid differentiation primary response gene 88; TIR, toll/Interleukin-1 receptor; IRAK4, IL-1 receptor-associated kinase 4; TRAF6, TNF receptor associated factor; AP-1, activator protein 1 IKK: IκB kinase; JNK, c-Jun N-terminal kinases; TCR, T-cell receptor; TNF-α, tumor necrosis factor-α; Il-6, Interleukin-6; LIF, leukemia inhibitory factor; Il-1ß, Interleukin-1ß Il-1; Acp, The IL-1 accessory protein; Gp130, Glycoprotein 130; JAK, Janus kinase; STAT, signal transducer and activator of transcription; CRP, C-reactive protein.