HEMA in Polymers with Thermoresponsive Properties

IF 11.1 2区化学 Q1 POLYMER SCIENCE

Polymer Reviews Pub Date : 2021-04-29 DOI:10.1080/15583724.2021.1896542

Maciej Kasprów, Daria Lipowska-Kur, Łukasz Otulakowski, A. Dworak, B. Trzebicka

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引用次数: 5

Abstract

Abstract This review presents the current state-of-knowledge concerning thermoresponsive copolymers containing 2-hydroxyethyl methacrylate (HEMA). The thermoresponsive copolymers based on HEMA, HEMA derivatives, and copolymers with modified HEMA units in the chain studied so far are presented. Information about their transition temperature in dilute water or buffer solution and the influence of various factors on their thermoresponsive properties described so far in the literature are reported. The research of the aggregation of HEMA containing thermoresponsive chains concern the morphology and size of nanoparticles formed upon heating. Using the available data, we tried to expose the impact of HEMA content in thermoresponsive chains on thermal properties of the copolymers. Modifications of the HEMA hydroxyl groups led to of thermoresponsive macromolecules with various structures and topologies. New functionality introduced by modification improves properties (stability, biocompatibility, and others) of the polymers and their aggregates. Thermal aggregation of HEMA-based copolymers allowing for the creation of carriers of biologically active substances, we presented in a separate part of the review. The works discussed in the review show significant possibilities for using HEMA in obtaining thermoresponsive polymer materials for medical applications.

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具有热响应特性的聚合物中的HEMA

摘要:本文综述了目前关于含2-羟乙基甲基丙烯酸酯(HEMA)的热敏性共聚物的知识状况。介绍了目前研究的基于HEMA的热敏共聚物、HEMA衍生物以及在链上修饰HEMA单元的共聚物。本文报道了它们在稀水中或缓冲溶液中的转变温度以及文献中所述的各种因素对其热响应性能的影响。含热响应链的HEMA聚集的研究涉及到加热后形成的纳米颗粒的形态和大小。利用现有的数据，我们试图揭示热敏链中HEMA含量对共聚物热性能的影响。HEMA羟基的修饰导致具有不同结构和拓扑结构的热响应性大分子。通过改性引入的新功能提高了聚合物及其聚集体的性能(稳定性、生物相容性等)。基于hema的共聚物的热聚集允许创造生物活性物质的载体，我们在评论的另一部分中提出。在审查中讨论的工作显示了使用HEMA获得用于医疗应用的热敏聚合物材料的重大可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polymer Reviews 工程技术-高分子科学

CiteScore

24.80

自引率

0.80%

发文量

审稿时长

6 months

期刊介绍： Polymer Reviews is a reputable publication that focuses on timely issues within the field of macromolecular science and engineering. The journal features high-quality reviews that have been specifically curated by experts in the field. Topics of particular importance include biomedical applications, organic electronics and photonics, nanostructures, micro- and nano-fabrication, biological molecules (such as DNA, proteins, and carbohydrates), polymers for renewable energy and environmental applications, and interdisciplinary intersections involving polymers. The articles in Polymer Reviews fall into two main categories. Some articles offer comprehensive and expansive overviews of a particular subject, while others zero in on the author's own research and situate it within the broader scientific landscape. In both types of articles, the aim is to provide readers with valuable insights and advancements in the field of macromolecular science and engineering.