METHOD FOR APPLICATION OF TRICLABENDAZOLE COMPLEX "TRICLAFASCID" FOR TREATMENT AND PREVENTION OF FASCIOLIASIS IN FARM ANIMALS

THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL Pub Date : 2023-04-17 DOI:10.31016/978-5-6048555-6-0.2023.24.331-336

M. Musaev, M. Khalikov

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Abstract

Among the most common and dangerous parasitic diseases of animals and humans is fascioliasis. The most effective against Fasciola is triclabendazole ("Fasinex 5.0%" suspension), imported by Siba-Geigi, which is practically not used in Russia due to its high cost. Considering the huge economic damage caused by fascioliasis, we have developed a new complex preparation using innovative mechanochemical technology based on the substance of triclabendazole "Triclafascid", which is 5 times more active than the substance of triclabendazole against fascioliasis. The drug is an intermolecular complex in the form of an easily flowing solid dispersed powder with a size of 0.1–10 microns. The drug is administered orally once to cattle and sheep for therapeutic and prophylactic purposes for acute and chronic fascioliasis, to sheep at a therapeutic dose of 2.0 mg/kg and to cattle 2.5 mg/kg for the AI, respectively, and 20 and 25 mg /kg for the drug, once individually in the form of an aqueous solution. In case of mass deworming of animals, it is convenient to give the anthelmintic by a group method to 10–20 animals, mixed with mixed feed at a dose of 3.0 mg/kg for the AI (for the preparation 30 mg/kg).

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三氯苄达唑复方“三拉法酸”治疗和预防农场动物片形吸虫病的方法

片吸虫病是动物和人类最常见和最危险的寄生虫病之一。对片形吸虫最有效的是Siba-Geigi进口的三氯苄唑(“Fasinex 5.0%”悬浮液)，由于其成本高，在俄罗斯实际上不使用。考虑到筋膜吸虫病造成的巨大经济损失，我们利用创新的机械化学技术，以三氯苄达唑物质为基础，研制出一种新型复合制剂，其抗筋膜吸虫病的活性是三氯苄达唑物质的5倍。该药物是一种分子间复合物，以易于流动的固体分散粉末的形式存在，尺寸为0.1-10微米。对牛和羊口服一次，用于治疗和预防急性和慢性片吸虫病，对羊口服治疗剂量分别为2.0 mg/kg和2.5 mg/kg，对牛口服治疗剂量分别为2.5 mg/kg，对药物口服20 mg/kg和25 mg/kg，单独一次以水溶液形式给药。在对动物进行大规模驱虫时，可以方便地将该驱虫剂按10-20只动物分组给药，与混合饲料混合，剂量为AI 3.0 mg/kg(制剂30 mg/kg)。

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THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL

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