Anticholinesterase and Antioxidant Potentials of a Medicinal Plant Abroma augusta: Implications for the Alternative Treatment Therapy of Cognitive Deficits in Alzheimers disease

Clinical Pharmacology & Biopharmaceutics Pub Date : 2015-10-28 DOI:10.4172/2167-065X.1000148

Mst. Marium Begum, K. Biswas, A. Sarker, Tamanna Binte Huq, Abeer Sarwar, Md. Belal Hossain, H. Tarek, Md. Noor A-Alam, Asma Rahman

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引用次数: 10

Abstract

Oxidative stress and low level of neurotransmitter (especially acetylcholine) are main characteristics of Alzheimer’s disease (AD), a progressive neurodegenerative disease. Prolonging the function of acetylcholine by inhibiting acetylcholinesterase or butyrylcholinesterase enzyme and reducing oxidative stress with antioxidants are most effective treatment therapy of AD. Abroma augusta is a well-known medicine plant with a variety of medicinal uses. In this study we examine cholinesterase inhibitory activity as well as antioxidant activity of dried fruit extract including crude methyl extract and its sub fractions (Chloroform fraction, Petroleum ether fraction, Ethyl acetate fraction and aqueous fraction) of A. augusta. Both cholinergic inhibitory activity and antioxidant activity of various fractions suggested that, ethyl acetate fraction are most prominent among all fractions and can be used in symptomatic treatment of AD.

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药用植物奥古斯塔抗胆碱酯酶和抗氧化潜能:对阿尔茨海默病认知缺陷的替代治疗的意义

氧化应激和低水平的神经递质(尤其是乙酰胆碱)是阿尔茨海默病(AD)的主要特征，它是一种进行性神经退行性疾病。通过抑制乙酰胆碱酯酶或丁基胆碱酯酶来延长乙酰胆碱的功能，并用抗氧化剂减轻氧化应激是AD最有效的治疗方法。奥古斯塔是一种著名的药用植物，具有多种药用价值。本文研究了奥古斯塔干果提取物的胆碱酯酶抑制活性和抗氧化活性，包括粗甲基提取物及其亚组分(氯仿组分、石油醚组分、乙酸乙酯组分和水组分)。各组分的胆碱能抑制活性和抗氧化活性均表明，乙酸乙酯组分在各组分中最突出，可用于AD的对症治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical Pharmacology & Biopharmaceutics

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