Association between Muscle Mass, Body Fat Mass, and Abdominal Circumstances with Insulin Resistance among Young Adult Population with Prediabetes Risk

Abstract

Prediabetesis is associated with an increase in plasma insulin concentration due to a decrease in insulin sensitivity in insulin target organs. Central obesity is a risk factor for prediabetes. To determine the relationship between muscle mass, body fat mass, and abdominal circumference with insulin resistance. The study was involving 50 young adult subjects aged 15-35 years, 50 subjects who met the inclusion and exclusion criteria. Muscle mass and body fat mass were measured using Bioelectrical Impedance Analysis (BIA). Abdominal circumference was measured using a tapemeter. Hours of sleep were measured using a questionnaire, while physical activity was measured based on the IPAQ-short form. Insulin resistances were measured using HOMA-IR score. Data were analyzed using spearman correlation. The correlation between abdominal circumference using two kinds of measurement and HOMA IR was found in all subjects (r = 0.691 and r 0.659; p = 0.000). After being analyzed separately by gender, it was found that there are positive correlation between body fat mass and HOMA-IR (male r = 0.672 p 0.001 female r = 0.582 p 0.001). There were a negative correlation between skeletal muscle mass and HOMA-IR (male r= -0.653 p 0.002, female r= -0.424, p 0.019), but there was no relationship between physical activity and sleep hours with insulin resistance. There is a relationship between skeletal muscle mass, fat mass, and abdominal circumference on insulin resistance regardless of gender. Further study is needed to determine the cutoff point of HOMA-IR as the predictor of insulin resistance.