Stress-Induced Hyperthermia in Translational Stress Research

C. Vinkers, R. Penning, M. Ebbens, J. Helhammer, J. Verster, C. Kalkman, B. Olivier
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引用次数: 14

Abstract

The stress-induced hyperthermia (SIH) response is the transient change in body temperature in response to acute stress. This body temperature response is part of the autonomic stress response which also results in tachycardia and an increased blood pressure. So far, a SIH response has been found in a variety of species (including rodents, baboons, turtles, pigs, impalas and chimpanzees), and there are indications that stress exposure alters body temperature in humans. This review aims to assess the translational potential and the different aspects of the body temperature reaction in response to stress. If stress-induced temperature changes are consistent across species, the SIH paradigm may be employed in preclinical and clinical setups and provide a tool to examine the pharmacological, genetic and mechanistic background of stress at both the preclinical and the clinical level.
转化应激研究中的应激诱导热疗
应激性热疗(SIH)反应是机体对急性应激反应的短暂性体温变化。这种体温反应是自主应激反应的一部分,它也会导致心动过速和血压升高。到目前为止,已经在许多物种(包括啮齿动物、狒狒、海龟、猪、黑斑羚和黑猩猩)中发现了SIH反应,并且有迹象表明压力暴露会改变人类的体温。这篇综述的目的是评估翻译潜力和体温反应的不同方面,以应对应激。如果压力引起的温度变化在不同物种之间是一致的,那么SIH模式可以用于临床前和临床设置,并提供一种在临床前和临床水平上检查压力的药理学,遗传学和机制背景的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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