Performances diagnostiques des anomalies graphiques dans la détection des macroplaquettes et des agrégats plaquettaires

Pathologie-biologie Pub Date : 2015-12-01 DOI:10.1016/j.patbio.2015.09.003

M. Sassi , W. Dibej , B. Abdi , F. Abderrazak , M. Hassine , H. Babba

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引用次数: 3

Abstract

Thrombocytopenia is a current situation for making a blood smear in routine practice in a medical analysis laboratory. Recent automated hematology analyzers enumerate platelets and generate histograms and specific flags. Operators must be aware of the characteristics of their analyzer in order to avoid spurious results in the case where microscopy review is not possible.

Objective

We evaluated the diagnostic performance of various graphical anomalies in the detection of large platelets and platelet clumps.

Patients and methods

Three hundred cases of thrombocytopenia were included in the study on the basis of a platelet count less than 150 × 10⁹/L. This evaluation is expressed by the results of the sensitivity, specificity, positive predictive value and negative predictive value compared to the microscopic review of blood smear.

Results

Graphical performances are variable according to microscopic review of blood smears. Indeed, a not fitted curve is the most sensitive change on platelet histogram to the presence of large platelet. A high specificity to the presence of platelet clumps is announced when the platelet curve fails to return to the baseline. Moreover, characteristic findings on the DIFF scattergram are very specific to the presence of platelet clumps.

Conclusion

A normal platelet histogram can validate with great confidence thrombocytopenia in cases where a blood smear cannot be read immediately.

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图形异常在检测血小板和血小板聚集中的诊断性能

血小板减少症是医学分析实验室在常规实践中进行血液涂片检查的现状。最近的自动化血液学分析仪枚举血小板并生成直方图和特定标志。操作人员必须了解其分析仪的特性，以避免在显微镜检查不可能的情况下产生虚假结果。目的评价各种图像异常对大血小板和血小板团块的诊断价值。患者与方法血小板计数小于150 × 109/L的300例血小板减少症患者纳入研究。这种评价是通过对比血液涂片镜检的敏感性、特异性、阳性预测值和阴性预测值的结果来表达的。结果血液涂片镜检结果不同，图像表现不同。事实上，不拟合曲线是血小板直方图上对大血小板存在最敏感的变化。当血小板曲线不能恢复到基线时，对血小板团块的存在具有高特异性。此外，DIFF散点图上的特征性发现非常特定于血小板团块的存在。结论在不能立即读血涂片的情况下，正常的血小板直方图可以很有信心地证实血小板减少症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathologie-biologie 医学-病理学

自引率

0.00%

发文量

审稿时长

6-12 weeks