Binding mode of Co(en) with calf thymus DNA

Laboratory Robotics and Automation Pub Date : 1999-08-31 DOI:10.1002/(SICI)1098-2728(1999)11:4<193::AID-LRA3>3.0.CO;2-S

Jingwan Kang, Jing Chen, Zhihua Wang, Xiaoquan Lu, Yumin Song, Jinzhang Gao

引用次数: 1

Abstract

The binding mode of Co(en) (en = ethylenediamine) to calf thymus DNA is investigated using electrochemical and spectroscopic methods. Binding constant value (K = 1.284 × 10³ L/mol) is found to be the same by the two methods. Both isomers show the same CV behavior associated with binding to B-form DNA. CD spectra results show no enantoselectivety for both isomers binding to DNA. All of this evidence suggests that the Co(en) complex binds to DNA by an electrostatic mode. © 1999 John Wiley & Sons, Inc. Lab Robotics and Automation 11: 193–196, 1999

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Co(en)与小牛胸腺DNA的结合方式

用电化学和光谱方法研究了Co(en) (en =乙二胺)与小牛胸腺DNA的结合模式。结果表明，两种方法的结合常数K = 1.284 × 103 L/mol相同。两种异构体在与b型DNA结合时表现出相同的CV行为。CD光谱结果表明，这两种异构体与DNA的结合都没有对映体选择性。所有这些证据都表明Co(en)复合物以静电模式与DNA结合。©1999 John Wiley &儿子,Inc。实验室机器人与自动化11:193-196,1999

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Laboratory Robotics and Automation

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