2-Pyridone quinoline hybrids as potent antibacterial and antifungal agents

IF 0.5 4区化学 Q3 Pharmacology, Toxicology and Pharmaceutics

Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-02-15 DOI:10.56042/ijcb.v60i2.35076

N. Desai, J. P. Harsorab, H. Mehtaa

引用次数: 5

Abstract

An efficient synthetic strategy for the synthesis of 6-amino-1-(((2-chloroquinolin-3-yl)methylene)amino)-2-oxo-4-(aryl)-1,2-dihydropyridine-3,5-dicarbonitriles is well described in this paper. Structures of synthesized compounds have been identified by standard spectroscopic techniques like 1 H NMR, 13 C NMR, IR and mass spectroscopy. Results of the biological activity reveals that electron withdrawing groups and presence of –OH group on meta position play a significant role for the increment in the antibacterial and antifungal activities respectively of 3a-j . In the present study, it has been observed that compounds 3i and 3e are the most active antimicrobials.

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2-吡啶酮喹啉杂交种作为有效的抗菌和抗真菌剂

本文介绍了一种合成6-氨基-1-((2-氯喹啉-3-基)亚甲基)氨基-2-氧-4-(芳基)-1,2-二氢吡啶-3,5-二碳腈的高效合成策略。合成化合物的结构已通过标准的光谱技术，如1h NMR, 13c NMR, IR和质谱进行了鉴定。生物活性结果表明，吸电子基团和-OH基团的存在分别对3a-j的抗菌活性和抗真菌活性的提高起着重要作用。在本研究中，已经观察到化合物3i和3e是最有效的抗菌素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry 化学-有机化学

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Indian Journal of Chemistry (Section B) is a leading monthly journal in Organic and Medicinal Chemistry started publishing from 1976. It publishes papers on organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry. Apart from full length papers, notes and communications, the journal publishes short reviews on frontline areas under the column " advances in Contemporary Research".