IoT-Based Reconfigurable Micropump for Drug Delivery Applications

Abstract

This paper introduces an Internet-of-Things (IoT) based, wirelessly reconfigurable, sufficiently miniaturized micropumping device more suitable for personalized cancer therapy. The final product is intended to be locally implanted in tumor tissue, with the anticancer drug stored in refillable reservoirs. The wireless system facilitates the analysis of the transmitted data instantly, thus enabling control and reconfiguration of the drug administration regimen. The system was successfully implemented, tested in vitro, and proven to deliver a model anticancer drug accurately and achieve a cytotoxic effect on breast cancer cells (>71%) with an optimized remotely controlled bolus dosing regimen. The proposed pumping solution is intended to improve the therapeutic performance of cancer drugs by reversing their resistance.