Effects of extracorporeal diaphragmatic pacing on pulmonary function and exercise endurance in patients with chronic respiratory failure

Abstract

Objective To study the effect of external diaphragmatic pacing on lung function and exercise endurance in patients with chronic respiratory failure. Methods There were 120 patients with chronic obstructive pulmonary disease admitted to Daxing Teaching Hospital, Capital Medical University from May 2017 to May 2018 selected as study subjects, and divided into observation group and control group by random number table method, with 60 cases in each group.Patients in the control group were given conventional treatment, and patients in the observation group were treated with extracorporeal diaphragmatic pacing on the basis of the control group.The indexes of forced expiratory volume in the first second, forced expiratory volume in the first second/forced vital capacity, forcad vital capacity, partical pressure of oxygen in artery, arterial oxygen saturation, partical pressure of carbon dioxide in artery, myoglobin, creatine kinase and lactate dehydrogenase before and after treatment in the two groups were compared.Chronic obstructive pulmonary disease assessment test and modified British medical research council (mMRC) scores before and after treatment were compared between the two groups. Results After treatment, the levels of forced expiratory volume in the first second, forced expiratory volume in the first second/forced vital capacity and maximum ventilation per minute in the observation group were significantly higher than those before treatment and after treatment in the control group (all P<0.05). The levels of partical pressure of oxygen in artery and arterial oxygen saturation in the observation group after treatment were significantly higher than those before treatment and after treatment in the control group (all P<0.05). Partical pressure of carbon dioxide in artery in the observation group was significantly lower than that before treatment and after treatment in the control group (all P<0.05). After treatment, the levels of myoglobin, creatine kinase and lactate dehydrogenase in the observation group were significantly lower than those before treatment and after treatment in the control group (all P<0.05). After treatment, the scores of cough, sputum, chest tightness, climbing, housework, confidence in outdoor activities, sleep and spirit in the observation group were significantly lower than those before treatment and after treatment in the control group (all P<0.05). There was no significant difference in mMRC grade between the two groups before treatment (Z=0.283, P=0.963). After treatment, the mMRC grade of the observation group was significantly lower than that of the control group (Z=9.318, P=0.025). Conclusions Extracorporeal diaphragmatic pacing for the treatment of chronic obstructive pulmonary disease can improve the patient′s lung function, relieve the patient′s clinical symptoms, improve exercise endurance, worthy of clinical application. Key words: Pulmonary disease, chronic obstructive; Respiratory function tests; External diaphragmatic pacing; Exercise endurance