Aberrant function of neutrophils in asthma

Abstract

Asthma is a chronic inflammatory airway disease, with an array of cells involved in the pathogenesis of the disease. The role of neutrophils in asthma pathogenesis is controversial. This review highlights the mechanisms of neutrophils about their aberrant functionality involved in asthma and factors contributed to impaired response to corticosteroids, which may contribute to a better understanding of asthma pathogenesis and consequently, facilitate the development of novel strategies for managing and treating neutrophilia in asthma.