Long-Term Dynamics of HIV-Infected Mortality and Risk Factors of the Lethal Outcome in the Presence and Absence of Concomitant Tuberculosis

V. I. Sergevnin, O. V. Tukacheva, O. E. Mikova, M. V. Rozhkova
{"title":"Long-Term Dynamics of HIV-Infected Mortality and Risk Factors of the Lethal Outcome in the Presence and Absence of Concomitant Tuberculosis","authors":"V. I. Sergevnin, O. V. Tukacheva, O. E. Mikova, M. V. Rozhkova","doi":"10.31631/2073-3046-2022-21-6-48-58","DOIUrl":null,"url":null,"abstract":"Relevance. The mortality rate of patients with HIV infection, including concomitant tuberculosis (HIV/TB), continues to increase. The goal of the work is to study the long­term dynamics of HIV­infected mortality and risk factors of the lethal outcome in the presence and absence of concomitant tuberculosis.Materials and methods. An assessment of the mortality rates of HIV­-infected people among the population of the Perm Region during the period from 2005 (the year of registration of the first cases of HIV/TB) to 2021 was carried out. In order to determine the life expectancy of patients and risk factors of the lethal outcome the analysis of 414 outpatient records of HIV­infected people who died in 2021 was carried out. The degree of immunodeficiency and viral load in patients was taken into account based on the results of examinations conducted in the period 6 months before the lethal outcome.Results. During the 15­year period of registration of the incidence of HIV/TB in the study area, 57.0% of those who died from causes directly related to HIV infection had TB. At the same time, despite the decrease in mortality from monotuberculous infection as a result of a decrease in the incidence of TB, in recent years there has been an increase in mortality from HIV/TB due to the intensification of the epidemic process of HIV infection. The average life expectancy of HIV­-infected people who died directly from HIV infection in the absence of TB was 6.7 ± 0.3 years, with concomitant TB ­5.7 ± 0.3 years. The lethal outcome of patients with HIV infection in the presence of TB and without TB was most often recorded with the number of CD4 + < 200 cells /ml and viral load > 100,000 copies /MBNA of HIV. At the same time, immunosuppression in deceased HIV/TB patients was more pronounced than in HIV­-infected patients in the absence of TB.","PeriodicalId":11736,"journal":{"name":"Epidemiology and Vaccinal Prevention","volume":"10 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epidemiology and Vaccinal Prevention","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31631/2073-3046-2022-21-6-48-58","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Relevance. The mortality rate of patients with HIV infection, including concomitant tuberculosis (HIV/TB), continues to increase. The goal of the work is to study the long­term dynamics of HIV­infected mortality and risk factors of the lethal outcome in the presence and absence of concomitant tuberculosis.Materials and methods. An assessment of the mortality rates of HIV­-infected people among the population of the Perm Region during the period from 2005 (the year of registration of the first cases of HIV/TB) to 2021 was carried out. In order to determine the life expectancy of patients and risk factors of the lethal outcome the analysis of 414 outpatient records of HIV­infected people who died in 2021 was carried out. The degree of immunodeficiency and viral load in patients was taken into account based on the results of examinations conducted in the period 6 months before the lethal outcome.Results. During the 15­year period of registration of the incidence of HIV/TB in the study area, 57.0% of those who died from causes directly related to HIV infection had TB. At the same time, despite the decrease in mortality from monotuberculous infection as a result of a decrease in the incidence of TB, in recent years there has been an increase in mortality from HIV/TB due to the intensification of the epidemic process of HIV infection. The average life expectancy of HIV­-infected people who died directly from HIV infection in the absence of TB was 6.7 ± 0.3 years, with concomitant TB ­5.7 ± 0.3 years. The lethal outcome of patients with HIV infection in the presence of TB and without TB was most often recorded with the number of CD4 + < 200 cells /ml and viral load > 100,000 copies /MBNA of HIV. At the same time, immunosuppression in deceased HIV/TB patients was more pronounced than in HIV­-infected patients in the absence of TB.
hiv感染死亡率的长期动态和存在和不存在合并结核病的致命结果的危险因素
的相关性。感染艾滋病毒的患者,包括合并结核病(艾滋病毒/结核病)的死亡率继续增加。这项工作的目标是研究艾滋病毒感染死亡率的长期动态以及存在和不存在合并结核病的致命结果的危险因素。材料和方法。对2005年(第一例艾滋病毒/结核病病例登记之年)至2021年期间彼尔姆地区人口中感染艾滋病毒者的死亡率进行了评估。为了确定患者的预期寿命和致命结果的风险因素,对2021年死亡的414名艾滋病毒感染者的门诊记录进行了分析。患者免疫缺陷程度和病毒载量是根据致死结果前6个月的检查结果来考虑的。在研究地区艾滋病毒/结核病发病率登记的15年期间,死于与艾滋病毒感染直接相关的原因的人中有57.0%患有结核病。与此同时,尽管由于结核病发病率的下降,单结核感染的死亡率有所下降,但近年来,由于艾滋病毒感染的流行进程加剧,艾滋病毒/结核病的死亡率有所上升。在没有结核病的情况下直接死于艾滋病毒感染的艾滋病毒感染者的平均预期寿命为6.7±0.3年,合并结核病的平均预期寿命为-5.7±0.3年。存在结核病和不存在结核病的HIV感染患者的致死结果最常记录为CD4 +细胞数< 200细胞/ml, HIV病毒载量为10万拷贝/MBNA。与此同时,在没有结核病的情况下,死亡的艾滋病毒/结核病患者的免疫抑制比艾滋病毒感染患者更为明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信