Clinical study on dry eye of keratoconus at different stages

中国实用眼科杂志 Pub Date : 2017-08-10 DOI:10.3760/CMA.J.ISSN.1006-4443.2017.08.009

Jing Du, Yong Li, Shengsheng Wei, Jing Li, Jian-guo Liu, Y. Wan

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Abstract

Objective To compare the dry eye characteristics of keratoconus at different stages and normal cornea. The dry eye features of keratoconus were analyzed. Methods Case-control study of 35 cases (44 eyes) of keratoconus were selected and divided into mild keratoconus 19 eyes, 15 cases with moderate keratoconus and 10 eyes with severe keratoconus according to Amsler-Krumeich grading method. Forty-four cases (44 eyes) as a normal corneal group. The dry eye characteristics were measured by the Keratograph dry eye comprehensive analyzer: First noninvasive tear break up time (NIBUT), mean NIBUT, tear river height, ocular index and meibomian gland absent area. And each patient was scored using the ocular surface disease index (OSDI) questionnaire. Using the T test, Wilcoxon rank sum test, variance analysis, Kruskal-Wallis H test. Results OSDI score of keratoconus group (40.96 ± 8.15) and normal cornea group (17.98 ± 5.50), the difference was statistically significant (t=10.864, P 0.05). There was no significant difference in the area of keratoconjunctival gland between different stages (F=1.555, P=0.226). Conclusions The study parameters indicate that keratoconus patients suffer greater symptoms and signs of dry eye, the difference of dry eye at different stages of keratoconus is significant. Key words: Dry eye; Keratoconus; Dry eye comprehensive analyzer

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圆锥角膜不同分期干眼的临床研究

目的比较不同阶段圆锥角膜与正常角膜的干眼特征。分析圆锥角膜的干眼特征。方法选择35例(44眼)圆锥角膜，按Amsler-Krumeich分级法分为轻度圆锥角膜19眼、中度圆锥角膜15眼、重度圆锥角膜10眼。正常角膜组44例(44眼)。采用角膜镜干眼综合分析仪测量干眼特征:首次无创撕裂时间(NIBUT)、平均NIBUT、泪河高度、眼指数、睑板腺缺失面积。采用眼表疾病指数(OSDI)问卷对患者进行评分。采用T检验、Wilcoxon秩和检验、方差分析、Kruskal-Wallis H检验。结果圆锥角膜组OSDI评分(40.96±8.15)分与正常角膜组(17.98±5.50)分比较，差异有统计学意义(t=10.864, P 0.05)。不同分期患者角膜结膜腺面积差异无统计学意义(F=1.555, P=0.226)。结论研究参数提示圆锥角膜患者干眼症状和体征较大，不同阶段圆锥角膜干眼差异显著。关键词:干眼症;圆锥形角膜;干眼综合分析仪

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中国实用眼科杂志

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期刊介绍： China Practical Ophthalmology was founded in May 1983. It is supervised by the National Health Commission of the People's Republic of China, sponsored by the Chinese Medical Association and China Medical University, and publicly distributed at home and abroad. It is a national-level excellent core academic journal of comprehensive ophthalmology and a series of journals of the Chinese Medical Association. China Practical Ophthalmology aims to guide and improve the theoretical level and actual clinical diagnosis and treatment ability of frontline ophthalmologists in my country. It is characterized by close integration with clinical practice, and timely publishes academic articles and scientific research results with high practical value to clinicians, so that readers can understand and use them, improve the theoretical level and diagnosis and treatment ability of ophthalmologists, help and support their innovative development, and is deeply welcomed and loved by ophthalmologists and readers.