Robotic Surgery for the Treatment of Chronic Pancreatitis: Pain Control, Narcotic Use Reduction and Re-Intervention Rate - Ten Years Followup Retrospective Study

Eduardo Fern, Es, Valentina Valle, G. A. Cornejo, Roberto Bustos, Robert Mangano, P. Giulianotti
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Abstract

Introduction: Surgical treatment of chronic pancreatitis is reserved to patients with intractable pain, pancreatic duct obstruction or suspicion of malignancy. Robotic surgery in this context has proven to be a safe and feasible. The aim of this study was to evaluate the effect of robotic assisted surgery in the context of chronic pancreatitis with regards to pain control, narcotic usage and need for re-intervention. Methods: A retrospective analysis of a prospectively collected divisional database at the University of Illinois Hospital & Health Sciences System was carried out. The primary endpoint was: 1) Evaluation of pre and post-operative pain and narcotic usage. The secondary endpoints were: 1) 10-year overall survival; and 2) ‘Event Free Survival’ (EFS). Results: 37 patients entered the study. The procedures performed were: pancreatic head resection (7), total pancreatectomy (1), hepatico-jejunostomy (6), longitudinal Roux-en-Y pancreato-jejunostomy (4), pancreatogastrostomy (14) and thoracoscopic splanchnicectomy (7). The mean pre and post-operative pain scores were 6.5 and 4.5 respectively (p<0.05, paired Student t-test). Rates of narcotics use pre and post-surgery were 74% and 50% of patients respectively. Re-intervention rates were: 57% for splanchnicectomies, 16% for hepatico-jejunostomies, 35% for pancreatogastrostomies, 1% for pancreatic resections and 25% for Puestow procedures. Splanchnicectomy group was the one to experience the shortest EFS compared to other groups (log-rank test, p<0.05). Conclusions: Robotic surgical treatment is an effective mean to symptoms control in chronic pancreatitis. Amongst the procedures taken into consideration, pancreatic resection, hepatico-jejunostomies and Puestow procedures appear to have the longest lasting beneficial effects
机器人手术治疗慢性胰腺炎:疼痛控制,减少麻醉品使用和再干预率- 10年随访回顾性研究
慢性胰腺炎的手术治疗是保留给顽固性疼痛,胰管阻塞或怀疑恶性肿瘤的患者。在这种情况下,机器人手术已被证明是安全可行的。本研究的目的是评估机器人辅助手术在慢性胰腺炎患者疼痛控制、麻醉使用和再次干预需求方面的效果。方法:对伊利诺伊大学医院与卫生科学系统前瞻性收集的分区数据库进行回顾性分析。主要终点为:1)评估术前、术后疼痛及麻醉使用情况。次要终点为:1)10年总生存期;2)“无事件生存”(EFS)。结果:37例患者进入研究。手术包括:胰头切除术(7)、全胰切除术(1)、肝空肠吻合术(6)、纵向Roux-en-Y胰空肠吻合术(4)、胰胃吻合术(14)和胸腔镜胰切除术(7)。术前和术后平均疼痛评分分别为6.5分和4.5分(p<0.05,配对学生t检验)。术前和术后麻醉药品使用率分别为74%和50%。再干预率为:胰切除术57%,肝空肠吻合术16%,胰胃吻合术35%,胰腺切除术1%,Puestow手术25%。与其他组相比,内脏切除术组的EFS最短(log-rank检验,p<0.05)。结论:机器人手术治疗是控制慢性胰腺炎症状的有效手段。在考虑的手术中,胰腺切除术,肝-空肠吻合术和Puestow手术似乎具有持续时间最长的有益效果
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