Colonic neuronal loss and delayed motility induced by high‐fat diet occur independently of changes in the major groups of microbiota in Swiss mice

Abstract

Obesity has been linked to gastrointestinal disorders, and the loss of myenteric neurons in the intestine caused by high‐fat diets (HFD) has been attributed to changes in microbiota and lipotoxicity. We investigated whether the prebiotic inulin modulates bacterial populations and alleviates neuronal loss in mice fed HFD.