Notice of RetractionPreparative Separation and Bioactivity of Flavonoids from Prunella Vulgaris Linn

2011 5th International Conference on Bioinformatics and Biomedical Engineering Pub Date : 2011-05-10 DOI:10.1109/ICBBE.2011.5780127

Shuang-li Xiong, Yingying Wang, Ni Huang

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Abstract

The characteristics of macroporous adsorption resins with different polarity on adsorption and isolation property of total flavonoids from Prunella Vulgaris Linn were performed by static and dynamic adsorption tests. Subsequently, the free radical and antimicrobial capacity of purified flavonoids were also evaluated. The results exhibited that AB-8 resin had higher absorption and desorption capacity. The optimum technology parameters of adsorption and separation were sample solution volume 3BV, sample solution concentration 1.6 mg/ml, velocity of flow 6BV/h. Adsorbted total flavonoids could be desorbed by 70% alcohol at flow rate 6BV/h, dosage 6BV. Compared to the 41.58% of total flavonoids in crude extracts, the recovery and purity of total flavonoids were 92.36% and 89.09% respectively. The DPPH radical scavenging activity of purified flavonoids was similar to antiscorbic acid which was much higher than that of butylated hydroxytoluene. It aslo had strong antimicrobial activity on Staphylococcus aureus and Escherichia coli (the diameters of the antimicrobial circle were 23.4mm and 21.2mm respectively). But it had no effect on Yeast and Aspergillus niger.

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夏枯草黄酮类化合物制备、分离及生物活性研究

通过静态和动态吸附实验，研究了不同极性大孔吸附树脂对夏枯草总黄酮的吸附和分离性能。随后，对纯化的黄酮类化合物的自由基和抗微生物能力进行了评价。结果表明，AB-8树脂具有较高的吸附和解吸能力。吸附分离的最佳工艺参数为样品溶液体积3BV，样品溶液浓度1.6 mg/ml，流速6BV/h。70%乙醇在流量6BV/h、用量6BV的条件下可解吸吸附的总黄酮。与粗提物中总黄酮的含量为41.58%相比，总黄酮的回收率和纯度分别为92.36%和89.09%。纯化的黄酮类化合物对DPPH自由基的清除能力与抗坏血酸相近，远高于丁基羟基甲苯。对金黄色葡萄球菌和大肠杆菌也有较强的抑菌活性(抑菌圈直径分别为23.4mm和21.2mm)。但对酵母菌和黑曲霉没有效果。

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2011 5th International Conference on Bioinformatics and Biomedical Engineering

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