Development of Graphene Oxide-Trihexyphenidyl Hydrochloride Nanohybrid and Release behavior

Current Environmental Engineering Pub Date : 2019-09-11 DOI:10.2174/2212717806666190313153239

P. Jawanjal, P. Patil, Jayesh Patil, Mrunal R. Waghulde, J. B. Naik

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引用次数: 2

Abstract

The demand of an efficient nanocarrier in drug delivery, graphene and its derivatives are emerging as a rising star due to its remarkable chemical and structural properties. Graphene oxide (GO) has high surface area and ability to load high amount of aromatic drugs. Hence, the objective of the research was to load Trihexyphenidyl hydrochloride (THP), antiparkinsonian drug on GO ultrasonically by π-π stacking interaction. GO was synthesized by the modified Hummer method. The conjugation of GOTHP was generated by using Design-Expert Software and release study of GO-THP nanohybrids was performed in the dissolution tester by using a dialysis membrane. By varying an amount of GO and THP, the effect on loading efficiency and drug release was studied. THP showed sustained release behavior with release efficiency of 89% to 98% over 8 h. GO-THP complex was characterized by UV-vis spectrophotometer, FTIR, FESEM and XRD analysis. GO-THP complex showed better-sustained release of the drug and can be useful for the reduction dose frequency as well as adverse effect with better patient compliance.

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氧化石墨烯-盐酸三己苯基纳米杂化材料的制备及其释放行为

石墨烯及其衍生物由于其卓越的化学和结构特性，在药物递送领域对高效纳米载体的需求日益旺盛。氧化石墨烯具有高表面积和负载大量芳香族药物的能力。因此，本研究的目的是通过π-π堆叠相互作用将抗帕金森药物盐酸三己苯酯(THP)超声加载到氧化石墨烯上。采用改进的Hummer法合成氧化石墨烯。利用Design-Expert软件生成GO-THP的偶联物，并利用透析膜在溶出仪中对GO-THP纳米杂交物的释放进行研究。通过改变氧化石墨烯和THP的用量，研究其对载药效率和释药效果的影响。在8 h内，THP的缓释效率为89% ~ 98%。采用紫外-可见分光光度计、FTIR、FESEM和XRD对GO-THP配合物进行了表征。GO-THP复合物具有较好的药物缓释作用，可用于减少剂量频率和不良反应，患者依从性较好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current Environmental Engineering

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