Mapping Human Reproduction with Single-Cell Genomics.

IF 7.7 2区生物学 Q1 GENETICS & HEREDITY

Annual review of genomics and human genetics Pub Date : 2022-05-13 DOI:10.1146/annurev-genom-120121-114415

Magda Marečková, H. Massalha, V. Lorenzi, R. Vento-Tormo

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引用次数: 5

Abstract

The trillions of cells in the human body develop as a result of the fusion of two extremely specialized cells: an oocyte and a sperm. This process is essential for the continuation of our species, as it ensures that parental genetic information is mixed and passed on from generation to generation. In addition to producing oocytes, the female reproductive system must provide the environment for the appropriate development of the fetus until birth. New genomic and computational tools offer unique opportunities to study the tight spatiotemporal regulatory mechanisms that are required for the cycle of human reproduction. This review explores how single-cell technologies have been used to build cellular atlases of the human reproductive system across the life span and how these maps have proven useful to better understand reproductive pathologies and dissect the heterogeneity of in vitro model systems. Expected final online publication date for the Annual Review of Genomics and Human Genetics, Volume 23 is October 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

查看原文本刊更多论文

用单细胞基因组学绘制人类生殖图谱。

人体内数以万亿计的细胞是由两个极其特殊的细胞——卵母细胞和精子——融合而成的。这一过程对我们物种的延续至关重要，因为它确保了亲代遗传信息的混合并代代相传。除了产生卵母细胞外，女性生殖系统还必须为胎儿的适当发育提供环境，直到出生。新的基因组和计算工具为研究人类生殖周期所需的紧密时空调节机制提供了独特的机会。这篇综述探讨了单细胞技术如何被用于构建人类生殖系统的细胞图谱，以及这些图谱如何被证明对更好地理解生殖病理和解剖体外模型系统的异质性有用。预计《基因组学与人类遗传学年度评论》第23卷的最终在线出版日期为2022年10月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of genomics and human genetics 生物-遗传学

CiteScore

14.90

自引率

1.10%

发文量

期刊介绍： Since its inception in 2000, the Annual Review of Genomics and Human Genetics has been dedicated to showcasing significant developments in genomics as they pertain to human genetics and the human genome. The journal emphasizes genomic technology, genome structure and function, genetic modification, human variation and population genetics, human evolution, and various aspects of human genetic diseases, including individualized medicine.