Developing docetaxel-loaded nanocapsules: A promising approach for cancer therapy

Cancer cell & microenvironment Pub Date : 2015-03-06 DOI:10.14800/CCM.689

I. Youm, V. Agrahari

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Abstract

This study has summarized the development of Docetaxel (DOC) loaded nanocapsules (NCs) intended for breast cancer (BC) therapy. These NCs are composed of a lipid core to encapsulate the hydrophobic DOC and a polymeric shell for surface functionalization. DOC was efficiently encapsulated within the oily core of NCs. The critical role of stabilizers on NCs stealthiness and anticancer drug efficacy was investigated. The potential impact of surface chemistry on the cytotoxicity and phagocytic clearance of NCs for a subsequent improvement of the efficacy of DOC in BC treatment was explored. The in vitro cell culture studies in cancer cell lines showed a significant enhancement of the cytotoxicity of DOC due to its high loading within the NCs. Interestingly, the NCs were stable during storage and could be efficiently transformed into powder form using freeze-drying method. It is also hypothesized that DOC-loaded hyaluronic acid (HA) grafted oily core NCs can enhance the drug cytotoxicity and uptake in CD44 expressing BC cells (MDA-MB 231). These novel nanostructures hold the promise to support the potential clinical application and cost-effectiveness of innovative nanotherapeutics in cancer therapy.

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开发装载多西他赛的纳米胶囊:一种有前途的癌症治疗方法

本研究综述了用于乳腺癌治疗的多西紫杉醇(DOC)负载纳米胶囊(NCs)的发展。这些NCs由一个脂质核和一个用于表面功能化的聚合物壳组成。DOC被有效地包裹在nc的油芯中。研究了稳定剂对神经网络隐蔽性和抗癌药物疗效的关键作用。探讨了表面化学对nc细胞毒性和吞噬清除的潜在影响，从而提高DOC治疗BC的疗效。肿瘤细胞系的体外细胞培养研究表明，由于其在nc内的高负荷，DOC显著增强了细胞毒性。有趣的是，NCs在储存过程中是稳定的，并且可以通过冷冻干燥方法有效地转化为粉末形式。也有人假设载doc透明质酸(HA)移植的油核nc可以增强表达CD44的BC细胞的药物细胞毒性和摄取(MDA-MB 231)。这些新型纳米结构有望支持创新纳米疗法在癌症治疗中的潜在临床应用和成本效益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer cell & microenvironment

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