Chicken Polymorphism at Pre-MicroRNAs Inferred from SNP Data

Chuan-sheng Zhang, Liying Geng, Jin Zhang, Wen-jin Zhu, L. Du
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引用次数: 1

Abstract

In this study, the SNPs located in the chicken pre-microRNAs were performed a genome-wide analysis. The result showed that pre-microRNA SNPs are negatively selected in respect to SNPs distribution between the pre-microRNA and their flanking regions. Interestingly, the seed regions show a higher SNP density than both the MIR and the other MIR regions excluding seed regions. Furthermore, the SNPs in the seed regions were found show fewer effects on the stability of the pre-microRNA secondary structure. The data suggest that there is a rapid evolution has occurred in the seed regions and these SNPs are tend to be more deleterious , being good candidates for causal phenotypic variability among chickens. These findings will improve our understanding of the functions, evolution of chicken pre-microRNAs
从SNP数据推断鸡pre - microrna多态性
本研究对鸡pre- microrna中的snp进行了全基因组分析。结果表明,pre-microRNA snp在pre-microRNA及其侧翼区域之间的snp分布是负选择的。有趣的是,种子区显示出比MIR和除种子区外的其他MIR区域更高的SNP密度。此外,种子区的snp对pre-microRNA二级结构的稳定性影响较小。这些数据表明,在种子区发生了快速的进化,这些snp往往更有害,是鸡之间因果表型变异的良好候选者。这些发现将提高我们对鸡pre- microrna的功能和进化的理解
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