Evaluation of Anti-Psoriatic Effects of Ellagic Acid on Imiquimod Induced Psoriatic-Like Dermatitis in Mice

Abstract

Ellagic acid is polyphenolic compound which is present in many fruits. Many pharmacological properties of Ellagic acid have been reviewed and described for many years. Some properties study in animals, while the other have been evaluated in humans including anti-inflammatory, neuroprotective, and Hepatoprotective effects, as well as the protection it provides against diabetes, cardiovascular disease, and cancer. In this study we investigated the effect of Ellagic acid on induced psoriatic-like dermatitis in mice. In this study, 50 mice were involved, divided into 5 groups (10 group of each). Except Group I (healthy), all group received Imiquimod for psoriasis induction during all days of experiment. Group II Induced and without treatment and the other groups III, IV and V were induced and treated twice daily with wool fat, 0.05% Clobetasol propionate, 5% Ellagic acid respectively, from day 7 until the end of experiment. The result showed that Ellagic acid has anti-psoriatic effect by significant decreasing the PASI score and ameliorating the histological changes that induced by IMQ and by significant decreasing the concentration of skin TNF-alpha as compared to induced group (II), and also significant decreasing the concentration of skin VEGF and pJAK3 as compared to induced group II and vehicle group III. In conclusion, the therapeutic effect of Ellagic acid against Imiquimod-induced psoriasis probably through mechanistic pathway involved anti-inflammatory, anti-proliferative and anti-angiogenesis effect.