Optical coherence tomography of retinal and choroidal layers in patients with familial hypercholesterolaemia treated with lipoprotein apheresis

4区医学 Q1 Medicine

Atherosclerosis. Supplements Pub Date : 2019-12-01 DOI:10.1016/j.atherosclerosissup.2019.08.031

Claudia Stefanutti , Dario Mesce , Fernanda Pacella , Serafina Di Giacomo , Paolo Turchetti , Michele Forastiere , Edoardo Trovato Battagliola , Giuseppe La Torre , Gianpaolo Smaldone , Elena Pacella

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引用次数: 9

Abstract

Purpose

Detect and quantify morpho-functional alterations of the retina and choroid in patients affected by familial hypercholesterolemia (FH) treated with lipoprotein apheresis (LA) using optic coherence tomography (OCT) and optic coherence tomography-angriography (OCTA).

Design

Observational study.

Subjects

To be diagnosed: A group of 20 patients (40 eyes) being clinically and genetically diagnosed as FH and under treatment (FH-Group)”, for at least 2 years, was compared to a control group of 20 healthy subjects (40 eyes), with a normal lipid profile and no ocular disease (CT-Group).

Methods

Participants were studied with the slit lamp, binocular indirect fundoscopy, OCT and OCTA.

Main outcome measures

Best corrected visual acuity (BVCA), spherical equivalent (SE), intraocular pressure (IOP), central macular thickness (CMT), choroidal thickness (CHT), retinal nerve fiber layer in four quadrants (RNFL (Superior = Sup; Inferior = Inf; Nasal = Nas Temporal = Temp), and the mean value across the four quadrants (RNFL G), foveal avascular zone (FAZ) and vascular density (VD).

Results

FH subjects had smaller RNFL superiorly (108 ± 19,38 μm OD/111 ± 16,56 μm OS FH-Group vs 127 ± 7,42 μm OD/129 ± 14,64 μm OS CT-Group; P < 0,001 for both OD and OS) and inferiorly (108 ± 23,58 μm OD/115 ± 17,33 μm OS FH-Group vs 128 ± 18,15 μm OD/133 ± 17,38 μm OS CT-Group; P = 0,002 OD; P = 0,001 OS). G RNFL was consequently smaller (93 ± 12,94 μm OD/94 ± 10,49 μm OS FH-Group vs 101 ± 9,01 μm OD/101 ± 10,20 μm OS CT-Group; P = 0,03 OD; P = 0,02 OS). FH subjects had a larger FAZ (0,31 ± 0,08 mm² OD/0,33 ± 0,10 mm² in OS FH-Group vs 0,21 ± 0,05 mm² OD/0,21 ± 0,07 mm² OS CT-Group; P < 0,001 OD; P = 0,002 OS).

Conclusions

Early signs of retinal vessel damage in FH patients can be detected and quantified with OCT and OCTA.

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用脂蛋白分离术治疗家族性高胆固醇血症患者视网膜和脉络膜层光学相干断层扫描。

目的利用光学相干断层扫描(OCT)和光学相干断层扫描血管造影(OCTA)检测并量化家族性高胆固醇血症(FH)患者接受脂蛋白分离(LA)治疗后视网膜和脉络膜的形态功能改变。DesignObservational研究。待诊断的受试者:一组20名(40只眼睛)经临床和遗传学诊断为FH并正在接受治疗的患者(FH组)，至少治疗2年，与对照组20名健康受试者(40只眼睛)进行比较，对照组血脂水平正常，无眼部疾病(ct组)。方法采用裂隙灯、双眼间接眼底镜、OCT和OCTA对患者进行观察。主要观察指标:最佳矫正视力(BVCA)、球面当量(SE)、眼内压(IOP)、黄斑中心厚度(CMT)、脉络膜厚度(CHT)、视网膜神经纤维层四个象限(RNFL (Superior = Sup;劣质 = 正无穷;鼻腔 = Nas颞 = Temp)，以及四个象限的平均值(RNFL G)、中央凹无血管区(FAZ)和血管密度(VD)。ResultsFH受试者小RNFL优(108 ± 19日38 μm OD / 111 ± 16日56 vs 127μm OS FH-Group ± 7,42 μm OD / 129 ± 14日64 μm OS CT-Group;P & lt; 0001 OD和操作系统)和下级(108 ± 23日,58 μm OD / 115 ± 17日33 vs 128μm OS FH-Group ± 18日15 μm OD / 133 ± 17日,38 μm OS CT-Group;P = 0002 OD;P = 0001操作系统)。G RNFL因此较小(93 ± 12日94 μm OD / 94 ± 10,49 vs 101μm OS FH-Group ± 9日01 μm OD / 101 ± 10,20 μm OS CT-Group;03 OD P = 0;P = 0,02年OS)。跳频受试者更大的《法兰克福汇报》(0,31 ± 0,08年 平方毫米OD / 0, 33 ± 0,10 平方毫米OS FH-Group vs 0, 21 ± 0 05 平方毫米OD / 0, 21 ± 0,07年 平方毫米OS CT-Group;P & lt; 0001年 OD;P = 0002操作系统)。结论使用OCT和OCTA可以检测和量化FH患者视网膜血管损伤的早期征象。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Atherosclerosis. Supplements 医学-外周血管病

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Atherosclerosis brings together, from all sources, papers concerned with investigation on atherosclerosis, its risk factors and clinical manifestations.