The role of growth hormone for fertility in women with hypopituitarism

IF 1.6 4区 医学 Q4 CELL BIOLOGY
Julie Chen , Laurence Katznelson
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引用次数: 0

Abstract

Growth hormone (GH) is an important regulator of the female reproductive system. In vitro and non-human in vivo studies demonstrate a role of GH in steroidogenesis, folliculogenesis, and post-fertilization development. Given its ability to modulate the reproductive system and potentiate the effects of gonadotropins, a beneficial role of GH replacement therapy to optimize fertility has been suggested. Women with hypopituitarism have lower pregnancy and live birth rates. Limited data suggest a role of GH in enhancing fertility management in women with hypopituitarism. GH replacement therapy may be especially relevant in women with hypopituitarism as well as in women considered poor ovarian responders and require assisted reproductive techniques.

生长激素在垂体功能低下妇女生育中的作用
生长激素(GH)是女性生殖系统的重要调节因子。体外和非人类体内研究表明生长激素在类固醇生成、卵泡生成和受精后发育中的作用。鉴于其调节生殖系统和增强促性腺激素作用的能力,已经提出了生长激素替代疗法在优化生育能力方面的有益作用。垂体功能减退的妇女怀孕率和活产率较低。有限的数据表明生长激素在增强垂体功能低下妇女生育管理中的作用。生长激素替代疗法可能特别适用于垂体功能低下的妇女,以及被认为卵巢反应不良和需要辅助生殖技术的妇女。
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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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