The Potential of N-acetyl Cysteine in Behavioral Addictions and Related Compulsive and Impulsive Behaviors and Disorders: a Scoping Review.

Q2 Arts and Humanities

Transactions of the Royal Historical Society Pub Date : 2022-12-01 Epub Date: 2022-09-29 DOI:10.1007/s40429-022-00446-3

Norman R Greenberg, Farzaneh Farhadi, Benjamin Kazer, Marc N Potenza, Gustavo A Angarita

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Abstract

Purpose of review: Behavioral addictions (also termed disorders due to addictive behaviors) contain impulsive and compulsive features and have been shown to involve glutamate dysregulation. N-acetylcysteine (NAC), a well-tolerated cysteine pro-drug and antioxidant, may reduce addictive behaviors by restoring glutamate homeostasis. The current review details and discusses the use of NAC in behavioral addictions and related impulsive and compulsive behaviors, including gambling disorder, problematic use of the internet, problematic video gaming, compulsive sexual behavior, problematic shopping/buying, problematic stealing, repetitive self-injurious behavior, and binge eating disorder.

Recent findings: Preliminary results have indicated the usefulness of NAC in gambling disorder, self-injurious behaviors, and compulsive sexual behaviors. Preclinical studies indicate that NAC is effective in improving binge eating behavior, but clinical trials are limited to a small open-label trial and case report. Studies are lacking on the efficacy of NAC in problematic use of the internet, problematic video gaming, problematic stealing, and problematic shopping/buying.

Summary: NAC demonstrates potential for use in behavioral addictions and compulsive behaviors, particularly in gambling disorder and self-injury. However, more studies are needed to assess the effectiveness of NAC in other behavioral addictions and the mechanisms by which NAC improves these conditions.

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N- 乙酰半胱氨酸在行为成瘾及相关强迫和冲动行为及障碍中的潜力：范围界定综述》（The Potential of N-acetyl Cysteine in Behavioral Addictions and Related Compulsive and Impulsive Behaviors and Disorders: a Scoping Review）。

综述的目的：行为成瘾（也称成瘾行为障碍）包含冲动性和强迫性特征，已被证明涉及谷氨酸失调。N-乙酰半胱氨酸（NAC）是一种耐受性良好的半胱氨酸原药和抗氧化剂，可通过恢复谷氨酸平衡来减少成瘾行为。本综述详细介绍并讨论了 NAC 在行为成瘾及相关冲动和强迫行为中的应用，包括赌博障碍、问题性使用互联网、问题性视频游戏、强迫性行为、问题性购物/购买、问题性偷窃、重复性自伤行为和暴饮暴食障碍：初步研究结果表明，NAC 对赌博障碍、自伤行为和强迫性行为有用。临床前研究表明，NAC 能有效改善暴饮暴食行为，但临床试验仅限于小型开放标签试验和病例报告。小结：NAC在行为成瘾和强迫行为方面，尤其是在赌博障碍和自我伤害方面具有潜在的应用价值。然而，还需要更多的研究来评估 NAC 对其他行为成瘾的有效性，以及 NAC 改善这些状况的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transactions of the Royal Historical Society Arts and Humanities-History

CiteScore

0.50

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0.00%

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期刊介绍： The Royal Historical Society has published the highest quality scholarship in history for over 150 years. A subscription includes a substantial annual volume of the Society’s Transactions, which presents wide-ranging reports from the front lines of historical research by both senior and younger scholars, and two volumes from the Camden Fifth Series, which makes available to a wider audience valuable primary sources that have hitherto been available only in manuscript form.