Peroxisome Proliferator- Activated Receptors (PPARs): A Review on Effects on Glucose Metabolism, Energy Homeostasis and Cardiovascular System

Abstract

Background: Molecular biology and human medical genetics have introduced several novel biomarkers giving control over vital body functions, of these are transcriptional factors known as peroxisome proliferator activated- receptors “PPARs”. The aim of this review is to shed light on available online information and published research works about these biomarkers. The current review will try to display those findings mainly related to energy homeostasis, glucose metabolism, insulin sensitivity and some cardiovascular interactions. Methods: a literature review about peroxisome proliferator activated- receptors and their roles in controlling some vital body functions has been made and recorded. Search covered published investigations and research works over the last three decades as accessible. Results: peroxisome proliferator activated- receptors have crucial roles in controlling a big deal of vital biological processes in humans. Conclusions: Peroxisome proliferator-activated receptors are important transcriptional factors with clinical impacts. Literature shows a wide spectrum of effects and interactions through affecting many genes involved in processes of glucose homeostasis, energy balance, and peripheral insulin sensitization in addition to interfering with processes of inflammation, angiogenesis, blood pressure control and atherosclerosis.