Synthesis, characterization and antibacterial activity of cyclohexyltin N-(salicylidene)valinates

Abstract

Abstract : Two new cyclohexyltin N- (salicylidene)valinates, [2-HOC 6 H 4 CH=NCH(CH(CH 3 ) 2 )COO]SnCy 3 ( 1 ) and [2-OC 6 H 4 CH=NCH(CH(CH 3 ) 2 )COO]SnCy 2 ( 2 ) (Cy = cyclohexyl), have been synthesized and characterized by elemental analysis, IR, and 1 H NMR. The crystal structure of 2 has been determined by X-ray single crystal diffraction. In the complexes, the carboxylate is monodentate. Complex 1 is a four-coordinated tin compound, and 2 has a distorted trigonal bipyramidal geometry with the axial locations occupied by one carboxylate oxygen and a phenolic oxygen of the ligand. Bioassay results show that 1 and 2 have good in vitro antibacterial activity against Escherichia coli .