Lung protection of remote limb ischemic preconditioning after pulmonary resection

Abstract

Objective To evaluate lung protection of remote limb ischemic preconditioning after pulmonary resection. Methods Methods sixty adult patients scheduled for elective pulmonary resection, were randomly divided into control group(group C, 30 cases) and remote limb ischemic preconditioning(group RLIP, 30 cases) using a random number table. Before one-lung-ventilation(T0), at 30 minites, 1 hour and 2 hours of OLV(T1, 2, 3), 15minites after re-expansion of the collapsed lung(T4), blood samples were drawn from the radial artery and vein for blood gas analysis, alveolar-arterial oxygen gradient(A-aDO2)、pulmonary shunt ratio(Qs/Qt)were calculated. Extraction time of closed thoracic drainage tube, length of hospital stay, the incidence of in-hospital complications after operation were recorded. Results Compared to T0 , each group at T1-T4, A-aDO2 were obviously increased. We found that at T3, A-aDO2 of group C increased much more higher and statistically significant(P 0.05). Conclusion Remote limb ischemic preconditioning had some protective effect after pulmonary resection, which mechanism may be related to enhancing autophagy in the operated 1ung tissues of the patients. Key words: Ischemic preconditioning; One-lung ventilation; Autophagy; Lung protection; Pulmonary shunt