Facile synthesis, thermal degradation and effective antimicrobial activities of Cu (II) complexes with bis [3-acetoxy-2-aryl/heteroaryl-4H-chromone]

Abstract

AbstractThis article reports the synthesis of bis [3-acetoxy-2-aryl/heteroaryl-4H-chromone] Cu (II) complexes 6(a–g) in 1:2 stoichiometry ratio of copper acetate and 3-acetoxy-2-aryl/heteroaryl-4H-chromone. While chelating ligands, active functionalized 3-acetoxyflavones (2-aryl/heteroaryl-3-acetoxy-4H-chromones) 5(a–g) are synthesized by Algar–Flynn–Oyamada transformation of chalcones (1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-ones) 4(a–g). The synthesized copper complexes are characterized by the standard techniques such as physical Fourier transform infrared spectroscopy (FT-IR), UV-reflectance spectroscopy, magnetic susceptibility and thermal analysis. Furthermore, antimicrobial activities are investigated using the standard methods. The antifungal activity was tested against Rhizoctonia solani and Candida tropicals, while antibacterial activity was screened against pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosa.