Electro-kinetic Investigations and Voltammetric Detection of Anti-ulcer Drug Cinitapride at Low-cost Pencil Graphite Electrode

Abstract

Abstract Herein, we proposed a cost-effective, eco-friendly, fast and sensitive square wave cathodic stripping voltammetry (SWCSV) and differential pulse cathodic stripping voltammetry (DPCSV) methods for the quantification of anti-ulcer drug cinitapride in pharmaceuticals. Cinitapride electrochemically reduced at pencil graphite electrode and gave an irreversible well-defined cathodic peak in cyclic, square wave, and differential pulse voltammograms. The effect of pH of buffer, scan rates, and drug concentration on peak current and peak potential were studied. The reduction of cinitapride at pencil graphite electrode was diffusion controlled and occurred via participation of two electrons and two protons (2e−/2H+). The various electro-kinetic parameters such as diffusion coefficient(Do), surface coverage (T o)and electron transfer coefficient (α) were calculated, additionally, the mechanism of reduction of cinitapride at pencil graphite electrode was also proposed. The peak currents vary linearly in the concentration range 2.48 μmolL−1 to 17.39 μmolL−1 for all the voltammetric techniques. The obtained value of LOD for SWCSV and DPCSV techniques were2.48 μmolL−1 and 3.19 μmolL−1, respectively, which proved higher sensitivity of the proposed methods. GRAPHICAL ABSTRACT