{"title":"Serotonin (5-HT) and pain: A reappraisal of its role in the light of receptor multiplicity","authors":"Mark J. Millan","doi":"10.1016/1044-5765(95)90005-5","DOIUrl":null,"url":null,"abstract":"<div><p>Centrifugal serotonergic pathways running from the rostroventral medulla (RVM) to the dorsal horn of the spinal cord have long been considered an integral component of mechanisms of ‘descending inhibition’ limiting the access of nociceptive information to higher centres. However, the hypothesis of a generalized antinociceptive role of these serotonergic projections no longer seems tenable. Indeed, multiple serotonin (5-HT) receptor types in the dorsal horn appear to fulfil <em>differential</em> roles in the control of nociception, reflecting their contrasting patterns of coupling to intracellular transduction mechanisms. Further, the importance of actions of 5-HT <em>outside</em> the dorsal horn should not be neglected. These aspects have been synthesized into a global view of the role of 5-HT in the control of nociception.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"7 6","pages":"Pages 409-419"},"PeriodicalIF":0.0000,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/1044-5765(95)90005-5","citationCount":"60","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/1044576595900055","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 60
Abstract
Centrifugal serotonergic pathways running from the rostroventral medulla (RVM) to the dorsal horn of the spinal cord have long been considered an integral component of mechanisms of ‘descending inhibition’ limiting the access of nociceptive information to higher centres. However, the hypothesis of a generalized antinociceptive role of these serotonergic projections no longer seems tenable. Indeed, multiple serotonin (5-HT) receptor types in the dorsal horn appear to fulfil differential roles in the control of nociception, reflecting their contrasting patterns of coupling to intracellular transduction mechanisms. Further, the importance of actions of 5-HT outside the dorsal horn should not be neglected. These aspects have been synthesized into a global view of the role of 5-HT in the control of nociception.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
