Lipid-Lowering Property of Flavonoid-Rich Portion of Combretum Micranthumon High Fat Diet Induced Hyperlipidemic Rats

International Journal of Bioscience, Biochemistry and Bioinformatics Pub Date : 2019-01-01 DOI:10.17706/IJBBB.2019.9.1.42-50

A. Babandi, N. Musa, M. Ya’u, H. Yakasai, D. Shehu, K. Babagana, A. Ibrahim

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引用次数: 2

Abstract

The lipid-lowering potential of flavonoid-rich portion of Combretum micranthum (CM) on a high-fat diet (HFD) induced albino rats was evaluated. Hyperlipidaemic rats were divided into six groups. Group I (Normal control), group II (HFD-fed only), while group III, IV and V received aqueous methanol (80%) leaf extract of CM at varied doses of 100, 200 and 400 mg/kg, respectively, while group VI were given the standard drugAtorvastatin (4 mg/kg) for two weeks. Total Cholesterol (TC), Triacylglycerol (TAG), High Density Lipoproteins (HDL-C), Creatine Kinase (CK), and Lactate Dehydrogenase (LDH) were assayed spectrophotometrically and Atherogenic Index (AI) calculated using standard formula. GC-MS revealed 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, 5-oxycatechol and 1,2,3benzenetriol to be the principal compounds. Significant reduction in TC, TAG, LDL-C, AI, CK, LDH and increased in HDL-C were observed compared to hyperlipidemic control (p<0.05) hence CM could be used in the management of risk of CVDs.

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高脂血症大鼠高脂饮食中富黄酮部分的降脂作用

研究了高脂饮食诱导的白化病大鼠的降脂作用。将高脂血症大鼠分为6组。I组(正常对照)、II组(仅饲喂hfd)， III、IV、V组分别给予100、200、400 mg/kg不同剂量的紫荆叶提取物水溶液(80%)，VI组给予标准药物阿托伐他汀(4 mg/kg)，疗程2周。分光光度法测定总胆固醇(TC)、三酰甘油(TAG)、高密度脂蛋白(HDL-C)、肌酸激酶(CK)、乳酸脱氢酶(LDH)，并用标准公式计算致动脉粥样硬化指数(AI)。GC-MS显示2,3-二氢-3,5-二羟基-6-甲基- 4h -吡喃-4- 1,5 -氧儿茶酚和1,2,3苯三醇是主要化合物。与高脂血症对照组相比，TC、TAG、LDL-C、AI、CK、LDH均显著降低，HDL-C升高(p<0.05)， CM可用于心血管疾病的风险管理。

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International Journal of Bioscience, Biochemistry and Bioinformatics

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