MODERN VIEW ON THE EPIDEMIOLOGY OF BREAST CANCER: A LITERATURE REVIEW

Oncologia i radiologia Kazakhstana Pub Date : 2022-09-30 DOI:10.52532/2521-6414-2022-3-65-37-41

R. Kumisbekova, N. Shanazarov, B. Bimbetov, M. Tuleutaev, D. Nigmetulla, E. Zhapparov

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Abstract

Relevance: Breast cancer (BC) is the leading cause of female cancer mortality worldwide. The constant development of treatment strategies and diagnostic tools has increased the survival rate for BC. Next-generation genome sequencing (NGS) identifies the genetic changes responsible for tumor emergence, development, and metastasis. NGS has expanded the capacities of BC diagnostics, treatment, and early prevention in women. The study aimed to identify breast cancer risk factors in women. Methods: Publications were obtained from the following databases: PubMed, Google Scholar, and eLibrary. The depth of the search was 5 to 10 years. As a result, 100 literary sources were identified, of which 26 publications formed the scientific material for this review. Results: Breast cancer is a heterogeneous disease driven by genetic abnormalities and epigenetic alterations. Conclusion: Gene mutations do not change. Genetic testing shall be introduced and used as a preventive measure to reduce BC incidence. Lifestyle-related BC risk factors can be modified to reduce BC risk.

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乳腺癌流行病学的现代观点:文献综述

相关性:乳腺癌(BC)是全球女性癌症死亡的主要原因。治疗策略和诊断工具的不断发展提高了BC的生存率。下一代基因组测序(NGS)确定了与肿瘤发生、发展和转移有关的遗传变化。NGS扩大了妇女BC诊断、治疗和早期预防的能力。这项研究旨在确定女性患乳腺癌的风险因素。方法:出版物从PubMed、Google Scholar和library数据库中获取。搜寻的深度是5到10年。结果，确定了100个文献来源，其中26个出版物构成了本综述的科学材料。结果:乳腺癌是一种由遗传异常和表观遗传改变驱动的异质性疾病。结论:基因突变未发生改变。基因检测应作为预防措施，以减少BC的发病率。与生活方式相关的BC危险因素可以通过调整来降低BC风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Oncologia i radiologia Kazakhstana

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