{"title":"Molecularly imprinted polymer combinatorial libraries for multiple simultaneous chiral separations","authors":"L. Sabourin, R. Ansell, K. Mosbach, I. Nicholls","doi":"10.1039/A806195E","DOIUrl":null,"url":null,"abstract":"We demonstrate that the ligand cross-reactivities of molecularly imprinted polymers can be beneficially employed for the simultaneous separation of different stereoisomeric structures. In this study, a limited molecularly imprinted polymer combinatorial library has been prepared and used for the simultaneous separation of a mixture of N-tert-butyloxycarbonyl-L-phenylalanine, N-tert-butyloxycarbonyl-D-phenylalanine, N-acetyl-L-phenylalaninyl-L-tryptophanyl methyl ester, N-acetyl-D-phenylalaninyl-D- tryptophanyl methyl ester, yohimbine and corynanthine.","PeriodicalId":7814,"journal":{"name":"Analytical Communications","volume":"1 1","pages":"285-287"},"PeriodicalIF":0.0000,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"29","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/A806195E","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 29
Abstract
We demonstrate that the ligand cross-reactivities of molecularly imprinted polymers can be beneficially employed for the simultaneous separation of different stereoisomeric structures. In this study, a limited molecularly imprinted polymer combinatorial library has been prepared and used for the simultaneous separation of a mixture of N-tert-butyloxycarbonyl-L-phenylalanine, N-tert-butyloxycarbonyl-D-phenylalanine, N-acetyl-L-phenylalaninyl-L-tryptophanyl methyl ester, N-acetyl-D-phenylalaninyl-D- tryptophanyl methyl ester, yohimbine and corynanthine.
我们证明了分子印迹聚合物的配体交叉反应性可以很好地用于不同立体异构体结构的同时分离。本研究制备了一个有限分子印迹聚合物组合文库,用于同时分离n -叔丁基氧羰基- l-苯丙氨酸、n -叔丁基氧羰基- d -苯丙氨酸、n -乙酰基- l-苯丙氨酸- l-色氨酸甲酯、n -乙酰基- d -苯丙氨酸- d -色氨酸甲酯、育亨宾和鸟角氨酸的混合物。