Enhancement of Anti-inflammatory Activities of Aronia melanocarpa through High-pressure Homogenization Process

Abstract

It was first confirmed that the increase of anti-inflammatory activities of Aronia melanocarpa from high-pressure homogenization at 25,000 psi and 25°C was caused by the three times higher extraction of very heat-labile cyanidin-3-O-galactoside (C3G), a bioactive anthocyanin existing in A. melanocarpa, than that of conventional 70% ethanol extraction at 80°C. The extracts from this process showed better efficacies in suppressing the production of both nitric oxide and the cytokines, IL-6 and TNF-α, and resulted in high liver weight gain in mice. This result could be employed to extract other heat-sensitive components from various bioresources.