In vitro Antibacterial Activity of Bioactive Potent Compounds from Terminalia chebula against Some Common Human Pathogens

S. Datta, N. Pal, A. Nandy
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引用次数: 4

Abstract

Objective: Emergence of community-acquired infections due to multi drug resistant (MDR) common human pathogens have caused a great problem to clinicians and this directed us to search systematically for a different remedy with compounds particularly from plant origin. Methods: The antibacterial activity was evaluated using agar well diffusion assay method against some common gram positive and gram negative bacteria. Results: In vitro study with Terminalia chebula Retz. (Combretaceae) stem bark extracts, eight isolated triterpenoids and four triterpenoid derivatives were found to be effective against Bacillus subtilis, Staphylococcus aureus, Salmonella typhi, Pseudomonas aeruginosa and Escherichia coli. Conclusions: Pure compounds from T.chebula could be effectively used as antibacterial agents if it is possible to develop the molecules synthetically. At the same time crude extracts with specified active principles could also be used and/or introduced in Traditional Medicine/Complementary Alternative Medicine (TM/CAM) as antibacterial into National/International Health Systems as per the guideline of Ayurvedic formularies.
chebula生物活性强效化合物对几种常见人类病原体的体外抗菌活性研究
目的:常见的人类病原体多药耐药(MDR)引起的社区获得性感染的出现给临床医生带来了很大的问题,这指导我们系统地寻找一种不同的药物,特别是植物来源的化合物。方法:采用琼脂孔扩散法对几种常见的革兰氏阳性菌和革兰氏阴性菌进行抑菌活性测定。结果:在体外研究了慈母的作用。(combretacae)茎皮提取物、8个分离的三萜和4个三萜衍生物对枯草芽孢杆菌、金黄色葡萄球菌、伤寒沙门氏菌、铜绿假单胞菌和大肠杆菌均有较好的抑制作用。结论:只要有可能进行分子合成,纯化后的板蓝藤化合物可作为有效的抗菌药物。同时,根据阿育吠陀处方指南,具有特定活性原理的粗提取物也可用于和/或在传统医学/补充替代医学(TM/CAM)中作为抗菌药物引入国家/国际卫生系统。
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