Relationship Between Consanguineous Marriages and Incidence and Severity of Refractive Errors: A Cross-sectional Study

A. Alsaqr
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引用次数: 3

Abstract

Congenital and genetic ocular disorders are linked to parental consanguinity. The aims was to investigate the effects of consanguineous marriages on the refractive errors of preschool-aged and adolescent patients. Two sample groups were recruited: the preschooler group (3–6 years; 335 participants) and the adolescent group (12–20 years; 998 participants). The required sample size was calculated using a sample size estimation software. Visual acuity was measured using the 15-line Lea symbols chart in the pre-school aged group and non-illuminated ETDRS VA chart in the adolescent group. Spherical equivalent refractive errors were noted with near-retinoscopy technique in young children and with the ARK-30 autorefractor in the adolescent group. In order to explore the impact of consanguineous marriages, the data were analyzed separately based on the age group using SPSS version 21 software. In the preschooler group, myopia was found in 4.2%, hyperopia in 8.1%, and astigmatism in 20%. Three children had high myopic scores (-10.00 D, -13.50 D and -17.50 D). In the adolescent group, 45.6% participants were myopic, 3.8% were hyperopic, and 22.3% were astigmatic. Despite the higher frequency of RE in those 15 years and older in the cousins group and the consanguineous parents of the three preschool-aged children with high myopia, there were no statistically significant (p>0.05) evidence that consanguineous marriages impact the refractive errors of their children. In conclusion, despite previous studies showing a link between ocular genetic or congenital disorders and consanguinity, no such link could be established with regard to refractive errors.
近亲婚姻与屈光不正发生率及严重程度的关系:一项横断面研究
先天性和遗传性眼部疾病与父母的血缘关系有关。目的是调查近亲婚姻对学龄前和青少年患者屈光不正的影响。分为两组:学龄前儿童组(3-6岁);335名参与者)和青少年组(12-20岁;998名参与者)。使用样本量估计软件计算所需的样本量。学龄前组采用15线Lea符号表测量视力,青少年组采用无照明ETDRS VA表测量视力。用近视网膜镜技术观察幼儿的球面等效屈光不正,用ARK-30自折射镜观察青少年组。为了探讨近亲婚姻的影响,使用SPSS 21版软件对数据进行了基于年龄组的单独分析。学龄前儿童近视发生率为4.2%,远视发生率为8.1%,散光发生率为20%。3名儿童近视得分较高(-10.00 D、-13.50 D和-17.50 D),青少年组近视得分为45.6%,远视得分为3.8%,散光得分为22.3%。尽管表兄妹组和3名学龄前高度近视儿童的近亲父母在15岁及以上发生屈光不正的频率较高,但近亲婚姻对其子女屈光不正的影响无统计学意义(p>0.05)。总之,尽管先前的研究显示了眼部遗传或先天性疾病与血缘关系之间的联系,但在屈光不正方面却没有这种联系。
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